Indeed after nearly a time of its worldwide irruption the SARS-Cov-2 contagion called COVID-19 continues to enjoy an edge over humankind which isn’t surprising considering the unknown extremity brought in by a contagion hardly known to anybody, its putatively picky approach in terms of mildness or inflexibility of the infection, thwarting all medical scientists and croakers. Humankind, in its present veritably advanced stage of the knowledge hunt, is noway a party to accept defeat, and thus, the hunt has been relentlessly going on each over for an effective vaccine, and in the meantime intent exploration onanti-viral oranti-malarial repurposed medicines, tube remedy and other possible styles of treatment. The main concern of all sweats being at least to reduce the mortality rates which also differcountry-wise and inexplicably, and till moment it has been an accepted fact that there’s no cure for the complaint. Colorful vaccine systems in colorful stages of development are in full swing in colorful countries with utmost of them promising a vaccine by the new time day or beforehand coming time. Now, the rearmost disappointing developments on treatment styles rehearsed so far have posed the most applicable question is an effective vaccine only hope for humankind?
Utmost of us remember the hopeless transnational pining for a principally covid medicine called Hydroxychloroquine (HCQ) when the epidemic was raging furiously in Europe and the US, and the US President going to the extent of hanging India if inventories of HCQ were not. Still, sluggishly over time this medicine was plant ineffective and a bit dangerous too in respect to natural impunity. Also there were several other medicines and steroids that were used with putatively hopeful results, Remdesivir being the one most ate one as a life- redeemer.
The results of the Solidarity Clinical Trial, one of the largest transnational Randomized Controlled Trials (RCT), that has been conducted by the World Health Organization (WHO) since March 2020 were declared lately which marked four of the most promising medicines as ineffective in reducing mortality. The four estimated treatment styles, HCQ, Remdesivir, Lopinavir or Ritonavir and Interferon, have been plant to have little or no impact on mortality rates. As far as the RCTs conducted in colorful countries of the world including in China are concerned there have always been dubieties on their findings, and experts feel the need for further similar studies. Expostulations were raised against the Solidarity Trial too as regards to its slice methodology from colorful diggings, with one Indian sanitarium refusing to stop using Remdesivir claiming its benefits over the months in their cases. Still, technically, it means that except for Corticosteroids which have been proven effective in treating critical cases there’s no other supposed treatment system, and it also must be remembered that steroids aren’t recommended for less-severe or general cases.
Further disappointing news came next from the Indian Council of Medical Research (ICMR) on the efficacity of the Convalescent Tube Remedy (CPT), so far permitted as an investigational remedy in progressive stages of the complaint in India, which involves taking out blood tube from recovered COVID-19 cases and fitting this antibody-rich excerpt into positive cases, particularly the more severe bones treated in hospitals. Over the months it has been developed into a methodical treatment system creating proper channels of donations across the countries as infected croakers too made it a point to contribute the precious tube.
The Director General of the ICMR declared the results on 20th October 2020 after conducting its own RCT during April-July period of the time covering over 400 hospitals across 39 medical centers of the country. Grounded on the results the ICMR has concluded that the CPT fails to reduce the mortality rates or help the progression of COVID-19 infections from moderate to severe stages. Following this chancing the Government of India is milling junking of CPT from its COVID-19 protocol for public clinical operation. This is indeed sad news as CPT has been a veritably popular system of COVID-19 treatment in the absence of an effective vaccine.
Experts, still, aren’t induced about the CPT results saying that it may have had to do with the detention of the infusion and the quality of the antibodies. Internationally, the CPT continues to be a treatment system meant only for exigency use. Anyway, in view of all these findings the significance of discovering an effective vaccine grows indeed more. The epidemic is far from keeping its clutches off humankind yet after over six months of erratic acceleration India has eventually reached its peak in the third week of September 2020 with new cases still swimming around fifty thousand a day and 500 diurnal deaths while the European countries and the US are passing a alternate surge.
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